Research & Innovation


Blafar Ltd is a research, development and manufacturing company specialising in high-quality and cutting-edge functionalised biopolymers for cosmetic and biomedical applications. Our focus lies in designing and developing innovative raw materials that offer advanced functionality, including functionalised hyaluronic acid and gelatin, collagen and hyperbranched poly (ethylene glycol). These materials combine excellent innate biological and mechanical characteristics with the world of synthetic chemical techniques to optimise biomechanical formulations and enhance outcomes in biomedical applications.

Blafar aims to significantly expand its market share and broaden the range of existing biomaterial products. We will continue to design and develop formulations using our multifunctional biomaterials, with a specific focus on introducing injectable scaffolds and 3D bio-ink products to the market. Under the exceptional leadership of Professor Wenxin Wang, supported by a highly skilled technical team, and leveraging our solid foundation in new technologies, we anticipate rapid growth for Blafar. We have already filed three patents for our technology and have secured licensing agreements for three new patented technologies from UCD. Blafar remains committed to ongoing research and innovation to deliver new and improved biomaterial products.

Blafar’s materials have applications in various fields of biomedical research

Tissue Engineering

Tissue engineering combines biology, engineering, and materials science to create functional artificial tissues and organs. By using biocompatible materials, scaffold structures, and cells, tissue engineering aims to regenerate damaged or lost tissues, offering potential solutions for organ transplantation, wound healing, and addressing degenerative diseases.

3D Cell Culture

3D cell culture has emerged as a powerful tool in biomedical research for studying cellular behaviour that bridges the gap between traditional cell culture models and in vivo systems by mimicking the complex architecture and functionality of human tissues. 3D cell culture techniques provide a more physiologically relevant environment by allowing cells to grow and interact in three dimensions.

3D Printing

3D printing has revolutionised biomedical research and clinical practice. It enables the creation of complex, patient-specific structures, implants, and scaffolds using biocompatible materials. 3D printing allows for precise customisation, facilitating advancements in medical devices and regenerative medicine.

Tissue Adhesives

Tissue adhesives are innovative substances used to bond biological tissues together. These adhesives provide an alternative to traditional sutures or staples, offering benefits such as reduced scarring, enhanced wound closure, and improved healing time. Tissue adhesives find applications in surgical procedures, wound closure, and tissue repair.

Drug Delivery

Drug delivery techniques focus on developing efficient methods to transport therapeutic substances to targeted sites within the body. The porous nature of hydrogels formed with Blafar’s biomaterials gives ideal conditions for drug encapsulation.

Funded Projects

Our commitment to pushing the boundaries of biopolymer technologies has led Blafar to engage in several projects funded by prominent Irish Funding Agencies, such as the Irish Research council and Science Foundation Ireland. These collaborative initiatives aim to realise the potential impact of our biopolymer technologies in improving the quality of life for patients worldwide.


(1)       Sanami, M.; Shtein, Z.; Sweeney, I.; Sorushanova, A.; Rivkin, A.; Miraftab, M.; Shoseyov, O.; O’Dowd, C.; Mullen, A. M.; Pandit, A.; Zeugolis, D. I. Biophysical and Biological Characterisation of Collagen/Resilin-like Protein Composite Fibres. Biomedical Materials (Bristol) 2015, 10 (6).

(2)       Moriarty, N.; Pandit, A.; Dowd, E. Encapsulation of Primary Dopaminergic Neurons in a GDNF-Loaded Collagen Hydrogel Increases Their Survival, Re-Innervation and Function after Intra-Striatal Transplantation. Sci Rep 2017, 7 (1).

(3)       Irizar, A.; Amorim, M. J. B.; Fuller, K. P.; Zeugolis, D. I.; Scott-Fordsmand, J. J. Environmental Fate and Effect of Biodegradable Electro-Spun Scaffolds (Biomaterial)-a Case Study. J Mater Sci Mater Med 2018, 29 (5).

(4)       Li, J.; Huang, Y.; Song, J.; Li, X.; Zhang, X.; Zhou, Z.; Chen, D.; Ma, P. X.; Peng, W.; Wang, W.; Zhou, G. Cartilage Regeneration Using Arthroscopic Flushing Fluid-Derived Mesenchymal Stem Cells Encapsulated in a One-Step Rapid Cross-Linked Hydrogel. Acta Biomater 2018, 79, 202–215.

(5)       Lee, H. J.; Fernandes-Cunha, G. M.; Myung, D. In Situ-Forming Hyaluronic Acid Hydrogel through Visible Light-Induced Thiol-Ene Reaction. React Funct Polym 2018, 131, 29–35.

(6)       Montalbano, G.; Fiorilli, S.; Caneschi, A.; Vitale-Brovarone, C. Type I Collagen and Strontium-Containing Mesoporous Glass Particles as Hybrid Material for 3D Printing of Bone-like Materials. Materials 2018, 11 (5).

(7)       Fuller, K. P.; Gaspar, D.; Delgado, L. M.; Shoseyov, O.; Zeugolis, D. I. In Vitro and Preclinical Characterisation of Compressed, Macro-Porous and Collagen Coated Poly-ϵ-Caprolactone Electro-Spun Scaffolds. Biomedical Materials (Bristol) 2019, 14 (5).

(8)       Montalbano, G.; Borciani, G.; Pontremoli, C.; Ciapetti, G.; Mattioli-Belmonte, M.; Fiorilli, S.; Vitale-Brovarone, C. Development and Biocompatibility of Collagen-Based Composites Enriched with Nanoparticles of Strontium Containing Mesoporous Glass. Materials 2019, 12 (22).

(9)       Leichner, C.; Jelkmann, M.; Bernkop-Schnürch, A. Thiolated Polymers: Bioinspired Polymers Utilizing One of the Most Important Bridging Structures in Nature. Advanced Drug Delivery Reviews. Elsevier B.V. November 1, 2019, pp 191–221.

(10)     Montalbano, G.; Molino, G.; Fiorilli, S.; Vitale-Brovarone, C. Synthesis and Incorporation of Rod-like Nano-Hydroxyapatite into Type I Collagen Matrix: A Hybrid Formulation for 3D Printing of Bone Scaffolds. J Eur Ceram Soc2020, 40 (11), 3689–3697.

(11)     Feng, X.; Zhou, T.; Xu, P.; Ye, J.; Gou, Z.; Gao, C. Enhanced Regeneration of Osteochondral Defects by Using an Aggrecanase-1 Responsively Degradable and N-Cadherin Mimetic Peptide-Conjugated Hydrogel Loaded with BMSCs. Biomater Sci 2020, 8 (8), 2212–2226.

(12)     Li, X.; Sigen, A.; Xu, Q.; Alshehri, F.; Zeng, M.; Zhou, D.; Li, J.; Zhou, G.; Wang, W. Cartilage-Derived Progenitor Cell-Laden Injectable Hydrogel-An Approach for Cartilage Tissue Regeneration. ACS Appl Bio Mater 2020, 3 (8), 4756–4765.

(13)     Chen, F.; Le, P.; Lai, K.; Fernandes-Cunha, G. M.; Myung, D. Simultaneous Interpenetrating Polymer Network of Collagen and Hyaluronic Acid as an in Situ-Forming Corneal Defect Filler. Chemistry of Materials 2020, 32 (12), 5208–5216.

(14)     Montalbano, G.; Borciani, G.; Cerqueni, G.; Licini, C.; Banche-Niclot, F.; Janner, D.; Sola, S.; Fiorilli, S.; Mattioli-Belmonte, M.; Ciapetti, G.; Vitale-Brovarone, C. Collagen Hybrid Formulations for the 3d Printing of Nanostructured Bone Scaffolds: An Optimized Genipin-Crosslinking Strategy. Nanomaterials 2020, 10 (9), 1–23.

(15)     Patel, M.; Koh, W. G. Composite Hydrogel of Methacrylated Hyaluronic Acid and Fragmented Polycaprolactone Nanofiber for Osteogenic Differentiation of Adipose-Derived Stem Cells. Pharmaceutics 2020, 12 (9), 1–15.

(16)     Kim, H.; Koh, W. G.; Lee, H. J. Effects of Basic Fibroblast Growth Factor Combined with an Injectable in Situ Crosslinked Hyaluronic Acid Hydrogel for a Dermal Filler. React Funct Polym 2021, 164.

(17)     Li, X.; Xu, Q.; Johnson, M.; Wang, X.; Lyu, J.; Li, Y.; McMahon, S.; Greiser, U.; Sigen, A.; Wang, W. A Chondroitin Sulfate Based Injectable Hydrogel for Delivery of Stem Cells in Cartilage Regeneration. Biomater Sci 2021, 9 (11), 4139–4148.

(18)     Banche-Niclot, F.; Montalbano, G.; Fiorilli, S.; Vitale-Brovarone, C. PEG-Coated Large Mesoporous Silicas as Smart Platform for Protein Delivery and Their Use in a Collagen-Based Formulation for 3D Printing. Int J Mol Sci 2021, 22 (4), 1–18.

(19)     Cai, Y.; Johnson, M.; Sigen, A.; Xu, Q.; Tai, H.; Wang, W. A Hybrid Injectable and Self-Healable Hydrogel System as 3D Cell Culture Scaffold. Macromol Biosci 2021.

(20)     Melo, P.; Montalbano, G.; Fiorilli, S.; Vitale-Brovarone, C. 3d Printing in Alginic Acid Bath of In-Situ Crosslinked Collagen Composite Scaffolds. Materials 2021, 14 (21).

(21)     Borciani, G.; Montalbano, G.; Melo, P.; Baldini, N.; Ciapetti, G.; Vitale-Brovarone, C. Assessment of Collagen-Based Nanostructured Biomimetic Systems with a Co-Culture of Human Bone-Derived Cells. Cells 2022, 11 (1).

(22)     Wang, X.; Li, X.; Duffy, P.; McMahon, S.; Wang, X.; Lyu, J.; Xu, Q.; A, S.; Chen, N. N.; Bi, V.; Dürig, T.; Wang, W. Resveratrol‐Loaded Poly( d , l ‐Lactide‐ Co ‐Glycolide) Microspheres Integrated in a Hyaluronic Acid Injectable Hydrogel for Cartilage Regeneration . Adv Nanobiomed Res 2022, 2 (1), 2100070.

(23)     Banche-Niclot, F.; Licini, C.; Montalbano, G.; Fiorilli, S.; Mattioli-Belmonte, M.; Vitale-Brovarone, C. 3D Printed Scaffold Based on Type I Collagen/PLGA_TGF-Β1 Nanoparticles Mimicking the Growth Factor Footprint of Human Bone Tissue. Polymers (Basel) 2022, 14 (5).

(24)     Hu, Y.; Cao, K.; Wang, F.; Wu, W.; Mai, W.; Qiu, L.; Luo, Y.; Ge, W. ping; Sun, B.; Shi, L.; Zhu, J.; Zhang, J.; Wu, Z.; Xie, Y.; Duan, S.; Gao, Z. Dual Roles of Hexokinase 2 in Shaping Microglial Function by Gating Glycolytic Flux and Mitochondrial Activity. Nat Metab 2022, 4 (12), 1756–1774.

(25)      Zhang, J.; He, Z.; Li, Y.; Shen, Y.; Wu, G.; Power, L.; Song, R.; Zeng, M.; Wang, X.; Sáez, I. L.; A, S.; Xu, Q.; Curtin, J. F.; Yu, Z.; Wang, W. Enhanced Gene Transfection Efficacy and Safety through Granular Hydrogel Mediated Gene Delivery Process. Acta Biomater 2023.

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